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WebThe mapping of a Ro52 interaction domain to Cul1 residues 452 to 603, the site of Rbx/Roc interaction, implies that Ro52 may serve a role similar to that of Rbx/Roc in an SCF-like E3 ligase complex. This interpretation is supported by the finding that Ro52-containing complexes display RING-dependent ubiquitination activity in vitro directed towards the … WebJan 1, 2024 · Request PDF On Jan 1, 2024, Ting Ma and others published Proapoptotic Effect of WS-299 Induced by NOXA Accumulation and NRF2-Counterbalanced Oxidative Stress Damage Through Targeting RBX1-UBE2M ... WebStudies in E. sinensis have shown that ubiquitination mediated by Cullin-RING E3 ligases (CRLs) plays important roles in spermatogenesis.In other species, CRLs are also essential in cell cycle progression, DNA replication, signal transduction, gene transcription, and development.The catalytic RING component, the RING box protein, is an important part of … how to shock treat a well