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Platinum ototoxicity

WebbDeterminants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer : A DCOG late-effects study: Published in: European Journal of Cancer, 69, 77 - 85. ... Cisplatin, Carboplatin, Ototoxicity, Childhood cancer, Munster classification, Furosemide, PEDIATRIC ONCOLOGY PATIENTS, PRACTICAL GRADING SYSTEM, INDUCED HEARING … WebbFor assessment of the ototoxic potential of carboplatin [cis-diammine-1,1-cyclobutane dicarboxylate platinum(II); CBDCA], pure-tone audiograms were evaluated in 27 patients …

Ototoxicity in Children Treated for Cancer

Webb11 aug. 2024 · RESEARCH TRIANGLE PARK, NORTH CAROLINA-- (Marketwired - Aug 11, 2024) - Fennec Pharmaceuticals Inc. ( FRX.TO) ( FENCF ), a specialty pharmaceutical company focused on the development of Sodium... WebbMechanistically, cisplatin ototoxicity is associated with the absence of glutathione (GSH) and the inhibition of glutathione peroxidase (GSH.Px) and glutathione reductase activities because cisplatin can covalently bind to the sulfhydryl groups of anti-oxidant enzymes, causing enzyme inactivation. 2 Increased lipid peroxidation in the cochlea … bar murale https://reneevaughn.com

Surveillance for ototoxicity in platinum-based chemotherapy using ...

Webb13 juni 2013 · Platinum chemotherapy drugs, such as cisplatin and carboplatin, are the cornerstone of many effective therapeutic protocols for childhood cancer. However, the … http://www.studyofnet.com/409971017.html WebbA clinical and pathologic study of cis-platinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. … bar mural pliant

Serum platinum levels and cisplatin induced ototoxicity among …

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Platinum ototoxicity

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Webb31 maj 2016 · Platinum-induced ototoxicity manifests clinically as a bilateral, progressive, and irreversible sensorineural hearing loss, leading to devastating consequences on the … Webb5 juli 2006 · Ototoxicity appears within hours-to-days after treatment with cisplatin 36 and results from cochlear hair cell damage, the distribution of which correlates with the …

Platinum ototoxicity

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http://mdedge.ma1.medscape.com/fedprac/article/227870/oncology/improving-ototoxicity-monitoring-cisplatin-therapy-va-northeast-ohio Webb1 mars 2024 · An extensive review of the literature revealed that a variety of criteria are used worldwide for grading platinum-induced hearing loss in children and adults, …

WebbCompositions and methods for reducing and/or preventing antibiotic-related damage to cells of the inner ear and the kidney are provided Such compositions and methods reduce or prevent hearing loss and kidney damage resulting from use of antibiotics, such as aminoglycoside antibiotics The composition also find use in reducing or preventing inner … WebbPlatinum ototoxicity was also attributed to free radical-induced cell damage, and antioxidant as well as platinum detoxifying mechanisms may protect from its …

Webbexacerbate ototoxicity, cochlear structures that are most vulnerable to platinum damage, therapies for reducing ototoxicity, and the molecular signaling pathways that lead to cell … Webb31 mars 2024 · Background: Platinum compounds are a group of fundamental chemotherapeutics used in the treatment of solid tumors, but they are burdened by side effects, such as ototoxicity. The objective of this study was to evaluate the incidence of ototoxicity caused by platinum compounds and [...] Read more.

WebbPlatinum levels were inversely correlated with time since diagnosis (Figure; r= -0.39). We will measure the association between blood serum platinum levels and ototoxicity, while …

WebbPlatinum compounds are a group of chemotherapeutic agents included in many pediatric and adult oncologic treatment protocols. The main platinum compounds are cisplatin, … bar muñoz majadahondaWebbPlatinum-based therapy is the mainstay for management of high-risk neuroblastoma. Prevalence of platinum-related ototoxicity has ranged from 13% to 95% in previous reports; variability is attributable to small samples and disparate grading scales. There is no consensus regarding optimal ototoxicity grading. suzuki j enginesWebbUnderstanding platinum-induced ototoxicity. by Thorsten Langer, Antoinette am Zehnhoff-Dinnesen, Susanne Radtke, Johannes Meitert, Oliver Zolk. Trends in pharmacological … bar mural ideas