WebbDeterminants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer : A DCOG late-effects study: Published in: European Journal of Cancer, 69, 77 - 85. ... Cisplatin, Carboplatin, Ototoxicity, Childhood cancer, Munster classification, Furosemide, PEDIATRIC ONCOLOGY PATIENTS, PRACTICAL GRADING SYSTEM, INDUCED HEARING … WebbFor assessment of the ototoxic potential of carboplatin [cis-diammine-1,1-cyclobutane dicarboxylate platinum(II); CBDCA], pure-tone audiograms were evaluated in 27 patients …
Ototoxicity in Children Treated for Cancer
Webb11 aug. 2024 · RESEARCH TRIANGLE PARK, NORTH CAROLINA-- (Marketwired - Aug 11, 2024) - Fennec Pharmaceuticals Inc. ( FRX.TO) ( FENCF ), a specialty pharmaceutical company focused on the development of Sodium... WebbMechanistically, cisplatin ototoxicity is associated with the absence of glutathione (GSH) and the inhibition of glutathione peroxidase (GSH.Px) and glutathione reductase activities because cisplatin can covalently bind to the sulfhydryl groups of anti-oxidant enzymes, causing enzyme inactivation. 2 Increased lipid peroxidation in the cochlea … bar murale
Surveillance for ototoxicity in platinum-based chemotherapy using ...
Webb13 juni 2013 · Platinum chemotherapy drugs, such as cisplatin and carboplatin, are the cornerstone of many effective therapeutic protocols for childhood cancer. However, the … http://www.studyofnet.com/409971017.html WebbA clinical and pathologic study of cis-platinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. … bar mural pliant