Peripherin
WebPeripherin is a class III intermediate filament subunit protein found in certain classes of neuron, most of which are located in the peripheral nervous system. Certain sensory neurons in the brain stem express peripherin normally, as do a few cortical and hoppocampal neurons. Interestingly, peripherin protein is upregulated in the lower motor ... WebPeripherin, a Triton-insoluble protein, whose distribution was found to be restricted to neurons in the rodent and human peripheral nervous system, was characterized by its electrophoretic features (isoelectric point: 5.6; molecular weight: 56,000 daltons) and by its peptidic map after limited proteolysis.
Peripherin
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Peripherin is a type III intermediate filament protein expressed mainly in neurons of the peripheral nervous system. It is also found in neurons of the central nervous system that have projections toward peripheral structures, such as spinal motor neurons. Its size, structure, and sequence/location of protein … See more Peripherin, first named such in 1984, was also known as 57 kDa neuronal intermediate filament prior to 1990. In 1987, a second distinct peripherally located retinal rod protein was also given the name peripherin. … See more Peripherin was discovered as being the major intermediate filament in neuroblastoma cell lines and in rat pheochromocytoma cells. … See more The complete sequence of the human (GenBank L14565), rat (GenBank M26232) and mouse (EMBL X59840) peripherin genes (PRPH) have been reported and complementary DNAs (cDNA) … See more Peripherin may be involved in the pathology of insulin-dependent diabetes mellitus (or diabetes mellitus type 1) in animals; however, no direct linkage has been found in … See more The diverse properties of intermediate filaments, compared with the conserved microtubule and actin filament proteins, could be responsible for the distinguishing molecular shapes of different cell types. In nerve cells, for example, the expressions of different types of … See more Protein and neurofilamentous aggregates are characteristic of patients with amyotrophic lateral sclerosis, a progressive, fatal neurodegenerative disease. Spheroids, specifically, which are protein aggregates of neuronal intermediate … See more Possible involvement of intermediate filaments such as peripherin in neurodegenerative diseases is currently being investigated. Interactions between intermediate filaments and other proteins are also being pursued. Peripherin has been shown to … See more WebApr 14, 2024 · VECTASHIELD®系列封片剂是用于免疫荧光应用中使用最广泛的防荧光淬灭封片剂。. 目前已有超过60.000篇的引用参考文献，这些文献数据表明该封片剂可与超过130种荧光基团和荧光标记物具有兼容性，也说明VECTASHIELD®系列封片剂产品在目前生物学研究领域的重要性 ...
WebPeripherin is a type III intermediate filament protein detected in axonal spheroids associated with amyotrophic lateral sclerosis (ALS). The overexpression of peripherin induces degeneration of spinal motor neurons during aging in transgenic mice and in cultured neuronal cells derived from peripherin transgenic embryos. WebPeripherin is a neuronal intermediate filament protein that is expressed chiefly in motor neurons and other nerve cells that project into the peripheral nervous system. Transgenic mice that over-express peripherin develop motor neuron degeneration, suggesting that mutations in peripherin could contribute to the development of motor neuron disease.
WebMar 21, 2008 · In addition, Robertson and colleagues have shown abnormal expression of a neurotoxic peripherin splice form in transgenic mouse models of ALS (Robertson et al., … WebAnti-Peripherin, clone 7C5, Cat. No. MAB5380-I is a mouse monoclonal antibody that detects Peripherin and is tested for use in Immunocytochemistry, Immunofluorescence, and Western Blotting. MAB5380-I-100UG 100 μg Price could not be retrieved Recommended Products Overview Supporting Documentation Related Product & Applications Overview …
WebPeripherin immunostaining was unequivocally identified in the cytoplasm of ganglion cells of patients at all ages. Of the 136 patients with diagnostic biopsies, 80% had ganglion …
WebApr 5, 2006 · Peripherin is a neuronal intermediate filament protein that is expressed chiefly in motor neurons and other nerve cells that project into the peripheral nervous system. Transgenic mice that over‐express peripherin develop motor neuron degeneration, suggesting that mutations in peripherin could contribute to the development of motor … rusich name originNeurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter and many micrometers in length. Together with microtubules (~25 nm) and microfilaments (7 nm), they form the neuronal cytoskeleton. They are believed to function primarily to provide structural support for axons and to regulate axon diameter, which influences nerve conduction velocity. The proteins that form neuro… schaumburg health clubWebPeripherin immunostaining was unequivocally identified in the cytoplasm of ganglion cells of patients at all ages. Of the 136 patients with diagnostic biopsies, 80% had ganglion cells. Of these, 93% of cases were diagnosed on the original eight levels. Twenty-seven cases were devoid of ganglion cells, and of these, 81% showed submucosal neural ... schaumburg granite cityWebAnti-Peripherin antibody [EPR23445-28] (ab246502) Research with confidence – consistent and reproducible results with every batch Long-term and scalable supply – powered by … schaumburg heating and coolingWebFeb 10, 2024 · It demonstrates that peripherin-2/rds (P/rds), a photoreceptor-specific protein associated with a broad range of inherited retinal diseases, shapes membranes to help build the distinctive architecture of photoreceptor OSs. More specifically, it reveals the normal function of P/rds as a curvature-generating protein that is essential for high ... schaumburg heating and cooling contractorWebMay 4, 2006 · Peripherin, a type III intermediate filament protein, was initially described by Portier et al. (1984) as a cytoskeletal protein present in neurons of the mammalian peripheral nervous system (hence, the name) and in … schaumburg high school baseball photosWebPeripherin, a Triton-insoluble protein, whose distribution was found to be restricted to neurons in the rodent and human peripheral nervous system, was characterized by its … rusich subway train