Olympia nct02032823
Web01. maj 2015. · Abstract. Background A Phase II study showed that the PARP inhibitor olaparib (400 mg bid; capsules) exerts antitumor activity in BC pts with a gBRCAm (Tutt et al Lancet 2010). Three Phase III trials of olaparib monotherapy have been initiated in BC pts with a gBRCAm: OlympiA (NCT02032823), Neo-Olympia (D081EC00005), OlympiAD … Web04. jul 2024. · OlympiA (NCT02032823) es un estudio aleatorizado de fase III, doble ciego, en el que se inscribieron pacientes con mutación BRCA1/2 de línea germinal, cáncer de mama triple negativo, HER2 negativo, o cáncer de mama temprano de riesgo alto, con receptores hormonales positivos después del tratamiento primario local y de la …
Olympia nct02032823
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Web케임브리지, 영국 -- 비즈니스와이어 -- 아스트라제네카(AstraZeneca)가 난소암 환자에 대해 백금기반 화학요법을 사용한 후 ‘린파자’(Lynparza)(성분명: 올라파립[olaparib])로 유지 치료하여 전체 생존기간(OS)이 연장된 것으로 나타난 Study 19임상시험의 3차 중간 분석 결과를 오늘 발표했다. 전체 생존기간 ... Web16. mar 2024. · OlympiA (NCT02032823) is a randomized, double-blind, parallel-group, placebo-controlled, multicenter, phase 3 study comparing olaparib to placebo in patients …
Web08. apr 2024. · More recently, the FDA also granted olaparib approval for adjuvant treatment of BRCA-mutated, HER2-negative high-risk early breast cancer, previously treated with chemotherapy in neoadjuvant or adjuvant scenarios, based on the OlympiA (NCT02032823) clinical trial . OlympiA was a phase III, double-blinded clinical trial with … Web10. jan 2014. · NCT02032823 Other Study ID Numbers: D081CC00006 NSABP B-55 ( Other Identifier: NSABP ) BIG 6-13 ( Other Identifier: Breast International Group ) First …
Web03. jun 2024. · Destacado como Late Breaking Abstract 1 no ASCO 2024, o estudo OlympiA mostrou que a adição de 1 ano do inibidor de PARP olaparibe após a conclusão do tratamento multimodal com quimioterapia (neo)adjuvante padrão, cirurgia e radioterapia, se indicada, melhorou significativamente a sobrevida livre de doença invasiva (IDFS) e a … Web14. jul 2016. · Bei der diesjährigen Tagung der AGO wurden zahlreiche Studien präsentiert, an denen österreichische Zentren aktiv beteiligt sind und deren Ergebnisse mit Spannung erwartet werden. Während die PARP-Inhibition beim BRCA-mutierten Ovarialkarzinom bereits erfolgreich etabliert wurde, muss ihre Effektivität beim Mammakarzinom erst …
Web18. jun 2024. · OlympiA研究纳入的患者在2014年就已开始入组,他们多是经过蒽环和紫杉类药物治疗后,再术后进行奥拉帕利一年辅助治疗。 然而在临床中,众所周知,经过新辅助治疗未能达到PCR的三阴性乳腺癌患者,其术后标准治疗实际上是采用卡培他滨进行强化治疗。
Web10. jun 2024. · Eine erste Zwischenanalyse der OlympiA-Studie zeigt eine signifikante Verbesserung des invasiven krankheitsfreien Überlebens bei Patientinnen mit HER2-negativem, BRCA1/2-Keimbahnmutiertem primärem Brustkrebs mit hohem Risiko nach 1 Jahr adjuvanter Behandlung mit dem PARP-Inhibitor Olaparib. helsinki seurakunta vaalikoneWeb18. mar 2024. · Approval was based on OlympiA (NCT02032823), a randomised (1:1), double-blind, placebo-controlled, international study of 1836 patients with germline … helsinki seurakuntaWeb23. mar 2024. · Adjuvant olaparib (Lynparza) induced a significant improvement in overall survival (OS) among previously treated patients with germline BRCA-mutated, HER2-negative, high-risk early breast cancer, according to findings of the OlympiA trial (NCT02032823) that were recently presented at the March 2024 ESMO Virtual Plenary.. … helsinki-seuraWeb10. jan 2014. · NCT02032823 Other Study ID Numbers: D081CC00006 NSABP B-55 ( Other Identifier: NSABP ) BIG 6-13 ( Other Identifier: Breast International Group ) First Posted: … helsinki shopWeb03. jun 2024. · (Funded by the National Cancer Institute and AstraZeneca; OlympiA ClinicalTrials.gov number, NCT02032823.) ... outside the United States. OlympiA is a … helsinki shoppailuWeb20. maj 2024. · Nachdem beim frühen Mammakarzinom die OlympiA-Studie ( [3]; NCT02032823) mit dem PARP-Inhibitor Olaparib ihren primären Endpunkt erreicht hat … helsinki shipyard uutisetWeb08. jun 2024. · Erika Hamilton, MD, Sarah Cannon Research Institute, Nashville, TN, speaks on the findings of OlympiA (NCT02032823), a randomized, double-blind, Phase III trial evaluating adjuvant olaparib after neoadjuvant chemotherapy in patients with germline BRCA1/2 mutations (gBRCAm) and high-risk HER2-negative early breast cancer. … helsinki shad rapala