WebNov 9, 2016 · Treatment with NSC 19630 (WRN inhibitor) induces S-phase cell cycle arrest, disruption of the mitochondrial membrane potential, and decreased expression of anti-apoptotic factor Bcl-2. These events were associated with activation of caspase-3-dependent apoptosis in ATL cells. WebTargeting the Werner (WRN) helicase to treat cancer Cancer cells that are defective in a specific type of DNA repair exhibit microsatellite instability (MSI) in their genomic DNA, and are strongly dependent on the function of the WRN protein for growth and viability.
Loss of a DNA repair system creates a unique vulnerability in …
WebMar 25, 2024 · We have included two SW480 monoclonal cell lines with an engineered deletion of WRN in order to assess the on-target activity of the WRN inhibitors. Both SW480 WRN knock-out lines display sensitivities lower or similar to the parental cell line or a WRN-proficient SW480 monoclonal cell line. In the absence of the protein target this indicates ... WebJun 28, 2024 · The WRN inhibitor developed selectively inhibits the helicase activity of WRN in the MSI-H (microsatellite highly unstable) cell line. Also developing targeting WRN are the WRN project of IDEAYA Biosciences and GSK, preclinical; the WRN project of Nimbus Therapeutics, preclinical; and the WRN inhibitor of Beactica Therapeutics, preclinical. norman rockwell silver coin set
Study Reinforces Treatment Idea for MSI-High Cancer - NCI
WebNov 15, 2024 · Clinical prospects of WRN inhibition as a treatment for MSI tumours. The discovery of synthetic lethal interactions with genetic deficiencies in cancers has … http://en.chomixbiotech.com/display.php?id=404 WebJun 16, 2024 · Inhibition of WRN inhibits the survival of MSI cancer cells, and in in vivo studies, Ideaya says it has observed 100% tumor growth inhibition ("TGI") in a cell line … norman rockwell signed lithographs for sale