WebMar 28, 1995 · One of these enzymes, ATP-dependent dethiobiotin synthetase, catalyzes the carboxylation of 7,8-diaminopelargonic acid leading to the formation of the ureido ring of biotin. The enzyme belongs to the class of ATP-dependent carboxylases and we present here the first crystal structure determined for this class of enzyme. WebNov 18, 2005 · Working model for the compartmentation of biotin metabolism in the plant cell. Biotin-synthesizing enzymes are as follows: 1, KAPA synthase; 2, DAPA aminotransferase; 3, dethiobiotin synthase; and 4, biotin synthase. The occurrence of reaction 2 in the cytosol and of reaction 3 in mitochondria is predicted from DNA …
ENZYME - 6.3.3.3 dethiobiotin synthase - Expasy
WebDethiobiotin synthase is involved in biotin biosynthesis and catalyses the reaction (CO2 + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP). The enzyme binds ATP (see motif in first 12 residues of the SEED alignment) and requires magnesium as a co-factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin] WebNov 1, 2012 · Biotin synthase is an S-adenosyl-l-methionine (SAM or AdoMet) radical enzyme that catalyzes reduction of the AdoMet sulfonium to produce 5′-deoxyadenosyl radicals, high-energy carbon radicals that can directly … sims 4 disney legacy challenge simfinity
UniProt
WebAug 17, 2024 · Mycobacterium tuberculosis dethiobiotin synthase ( Mt DTBS) is a crucial enzyme involved in the biosynthesis of biotin in the causative agent of tuberculosis, M. … WebBiotin synthase (BioB) catalyzes the insertion of a sulfur atom between the C6 and C9 carbons of dethiobiotin. Reconstituted BioB from Escherichia coli contains a [4Fe-4S]2+/1+ cluster thought to be involved in the reduction and cleavage of S-adenosylmethionine (AdoMet), generating methionine and the reactive 5′-deoxyadenosyl radical responsible … WebThis article is published in Journal of the American Chemical Society.The article was published on 1952-06-01. It has received 43 citation(s) till now. r. braxton hill iv