WebDec 26, 2024 · Mutation of Thr286 to alanine (i.e., T286A) was shown to reduce cyclin D1 polyubiquitination and stabilize the protein in proliferating and quiescent fibroblasts ( 24 ). GSK3β-mediated phosphorylation of … WebAug 8, 2024 · To detect whether cyclin D1 attributed to the NTCP down-regulation in proliferating cells, we transfected the constitutively active T286A mutant of cyclin D1 into …
Frontiers Degradation strategy of cyclin D1 in cancer cells and …
WebJul 1, 2010 · The decrease in cyclin D1 protein levels was associated with an inhibition in AKT and GSK-3beta phosphorylation, which correlated with an increase in cyclin D1-T286 phosphorylation. Fibroblasts carrying a mutant form of cyclin D1 (T286A) were resistant to PCB-153 induced degradation of cyclin D1. WebJul 10, 2024 · Cyclin D1 is an oncogene frequently overexpressed in human cancers that has a dual function as cell cycle and transcriptional regulator, although the latter is widely … hawks modular homes locations
Ubiquitination of Free Cyclin D1 Is Independent of …
WebCyclin D1 (Ab-286) antibody detects endogenous levels of total Cyclin D1 protein. Product Information. Source: Rabbit: Research Areas: Cell Cycle: Alternative Names: BCL-1 … WebSep 4, 2024 · Cyclin D1 is a key regulator of G1/S transition, and cell proliferation 7. Consistent with this role, in cancer cells, this molecule acts as an oncogene by promoting tumorigenesis and... WebJul 20, 1999 · NIH 3T3 cells were maintained in DMEM supplemented with 10% (vol/vol) FCS, antibiotics, and glutamine (GIBCO). NIH 3T3 cells engineered to overexpress Flag … hawks moments part 3