WebFeb 11, 2024 · Conclusions circRHOBTB3 plays a tumor-suppressive role in CRC and has to be excreted out of cells to sustain cancer cell fitness. ASOs targeting regulatory elements for circularization and... WebJun 2, 2024 · The molecular mechanism of circRHOBTB3 inhibits the proliferation and invasion of epithelial ovarian cancer by serving as the ceRNA of miR-23a-3p Rising evidences bespeak that circular RNAs are indispensable in regulating cellular biological behaviors and engaging in diseases' occurrence.
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WebFeb 11, 2024 · circRHOBTB3 was produced by splicing and circularization of the host gene RHOBTB3. As a Rho GTPase-family ATPase, the host gene RHOBTB3 is involved in membrane transport [ 8, 9] and proteasomal degradation [ 10] and can inhibit tumor growth by promoting the proteasomal degradation of HIF-α in renal cancer [ 11 ]. WebMechanistically, circRHOBTB3 binds to HuR, which is a ubiquitously expressed and functional RNA-binding protein (RBP) in CRC development, and promotes β-Trcp1-mediated ubiquitination of HuR. Normally, HuR binds to the 3'UTR of target mRNAs to facilitate their stabilization, whereas the interaction between circRHOBTB3 and HuR degrades HuR to ... diarrhea is spanish
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WebAmong them, 6 circRNAs (circBNC2, circEXOC6B, circFAM13B, circN4BP2L2, circRHOBTB3 and circCELSR1) have been associated with various clinicopathological features of epithelial ovarian cancer (EOC). More importantly, circEXOC6B and circN4BP2L2 may act as novel diagnostic biomarkers in patients with EOC . Another … WebView 10 photos for 263 Crestwood Cir, Benton, LA 71006, a 2 bed, 2 bath, 1,064 Sq. Ft. single family home built in 1984 that was last sold on 10/29/2024. WebArticle Title: The molecular mechanism of circRHOBTB3 inhibits the proliferation and invasion of epithelial ovarian cancer by serving as the ceRNA of miR-23a-3p Journal: Journal of Ovarian Research doi: 10.1186/s13048-022-00979-1 Figure Legend Snippet: CircRHOBTB3 is down-regulated in EOC. cities in bihar